Radiation interaction parameters for blood samples of breast cancer patients: an MCNP study

The main goal of this study was to determine radiation interaction parameters such as mass attenuation coefficients, effective atomic numbers, and effective electron densities depending on element concentrations (Na, K, Cu, Zn, Al, Ca, Mg Cr, Fe, Se) in blood samples of patients with breast cancer. Eighty blood samples were collected and analyzed in this study (40 from breast cancer patients and 40 from healthy patients). The determination of element concentrations of the samples was performed with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-optical emission spectrometry (ICP-OES) after which the element concentrations were normalized to percentage. Mass attenuation coefficients were calculated by Monte Carlo simulation method. In addition, effective atomic numbers and effective electron density values of the blood samples were calculated with the ZXCOM program. One of the most important results of this study is that differences in radiation interaction parameters between the two groups were observed. More specifically, the mass attenuation coefficients of the healthy group's blood samples were higher than those of the cancerous group at photon energies of 50 keV, 100 keV, 250 keV and 500 keV, while they were lower at 1 MeV. All the MCNP results were consistent with the results obtained from ZXCOM. As the main result of this study it is concluded that photon atomic parameters such as mass attenuation coefficient, effective atomic number and electron density may be considered in cancer diagnosis or treatment modalities.Türkiye Bilimsel ve Teknolojik Araştırma KurumuBAP Yildiz Technical Universit

Determination of Se, Cr, Mn, Zn, Co, Na, and K in blood samples of breast cancer patients to investigate their variation using ICP-MS and ICP-OES

The aim of this study was to investigate the concentration changes of Se, Mn, Cr, Zn, Co, Na and K in blood samples of breast cancer patients. Determination of the elements was performed using ICP-MS and ICP-OES instruments. Kolmogorov- Smirnov normality tests, Mann-Whitney U tests, Independent sample T tests and Spearman’s rank correlation tests were performed for statistical comparisons. It was found that the concentrations of Na and K in breast cancer patients were higher than for healthy people. The Se, Mn, and Cr concentrations were found to be lower in patients with breat cancer. No increase/decrease in Zn concentrations between the two groups was observed. A positive correlation was found between the distribution of Zn and K elements. Independent sample t and Mann- Whitney U tests demonstrated that statistical differences were observed between patients having the diagnosis of breast cancer and healthy people in terms of the concentrations of Se, Cr and Na. The results presented in this study will contribute to the literature by showing the relationship between breast cancer and element concentrations.2210C 2015-01-01-YL04, 832Yildiz Technical Universit

The effect of peroperatively and postoperatively used parasetamol on postoperative morphine consumption in spinal surgery

Amaç: Bu çalışmada; lomber disk cerrahisinde i.v. morfin ile yapılan hasta kontrollü analjeziye eklenen iv parasetamolün, postoperatif morfin tüketimi üzerine etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Hastane etik komitesi izni ve hasta onamları alındıktan sonra ASA I-III grubundan 67 erişkin olgu randomize olarak iki gruba ayrıldı. Grup M’ye (n=37) postoperatif olarak iv hasta kontrollü analjezi (HKA) ile morfin (bolus doz 1 mg, kilitli kalma süresi 10 dk. ve limit 50 mg 24 saat-1) verildi. Grup MP’ye (n=30) morfin HKA’ya ek olarak iv parasetamol (1 gr 15 dk. içinde infüzyon, 8 g 48 saat-1) verildi. Ayılma odasına alınan (0. dk.’da) ve Vizüel Analog Skala’sına göre skorları 3’ten büyük olan tüm olgulara fraksiyone dozlarda morfin yapıldı. Postoperatif 0., 30., 60. dk, 2., 4., 6., 12., 18., 24. ve 48. saatlerde sistolik arter basıncı, diyastolik arter basıncı, kalp atım hızı, periferik oksijen satürasyonu, solunum sayısı, hasta kontrollü analjezi istek sayısı, yanıtlanan hasta kontrollü analjezi istek sayısı, sedasyon skorları, VAS skorları, bulantı-kusma, kaşıntı ve döküntü varlığı kaydedildi. Ayrıca, fraksiyone morfin miktarları ve antiemetik tüketimi de kaydedildi. Bulgular: Fraksiyone morfin miktarları, total morfin tüketimi ve sedasyon skorları Grup MP’de daha düşük olarak bulundu (p<0.05). Grupların total morfin tüketim miktarları (Grup M’de 76.4±6.7 mg ve Grup MP’de 42.5±5.2 mg) arasındaki fark anlamlıydı (p<0.05). Ayrıca, ilk 2 saat VAS skorlarının da Grup M’de daha yüksek olduğu belirlendi (p<0.05). Tartışma ve Sonuç: Lomber disk cerrahisinden sonra, morfin ile uygulanan hasta kontrollü analjeziye iv parasetamol eklenmesinin, morfin tüketim miktarını azaltarak postoperatif analjezi kalitesini artırdığı kanısına varıldı.Aim: The aim of this study is to investigate the effects of iv paracetamol with iv morphine PCA on postoperative morphine consumption in lumbar disc surgery. Materials and Methods: After obtaining the approval of the hospital ethics committee and patient&amp;#8217;s consents, 67 adult patients, in ASA group&amp;#8217;s I-III, were randomly divided into two groups. Group M (n=37) received iv morphine Patient Control Analgesia (PCA) postoperatively (bolus dose 1 mg, lock out time 10 min, limited 50 mg 24 hrs-1). At the skin closure, iv paracetamol (1 g infused in 15 min, 8 g 48 hrs-1) was also administered with morphine PCA in Group MP. All the patients with Visual Analogue Scale (VAS) scores over 3 were administered iv morphine in fractioned doses at recovery room (0. minute). The systolic and diastolic arterial pressures, hearth rate, SpO2, breathing rate, PCA demand number, replied demand number and total morphine consumption, sedation scores, VAS scores, presence of nausea and vomiting, itching and patches were recorded at 0., 30., 60. min, 2., 4., 6., 12., 18., 24. and 48. hrs. Fractioned morphine amounts and antiemetic consumption were also recorded. Fractioned morphine amounts, total morphine consumption and sedation scores were found to be lowered in Group MP (p<0.05). The difference between the total morphine consumption amounts of the study groups (76.4±6.7 mg in Group M and 42.5± 5.2 mg in Group MP) were significant (p<0.05). In addition, the VAS scores of Group M were found to be higher in the first two hours (p<0.05). Conclusion: It is concluded that the combination of iv paracetamol and morphine PCA after spinal surgery enhances the quality of the postoperative analgesic effect of morphine PCA by lowering the morphine consumption amount

Correlation between Na/K ratio and electron densities in blood samples of breast cancer patients

The main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test. It was found that the electron densities significantly differ between control and breast cancer groups. In addition, statistically significant positive correlation was found between the electron density and Na/K ratios in breast cancer group

Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer

The main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000<0.05 and p=0.001<0.05, respectively) than for the healthy group, while the Al concentration was significantly lower (p=0.002<0.05) in the cancer patients. The Mg concentration in the control group and the patients was 33.60 +/- 4.51 and 38.10 +/- 9.69 mg/kg, respectively. The difference was statistically significant for Cu, Mg, and Al, whereas no difference was observed between the concentrations of Ca and Fe. Furthermore, a positive correlation was observed in breast cancer patients between the concentrations of (Al-Cu), (Al-Ca), (Fe-Mg), and (Cu-Ca)

Correlation between Na/K ratio and electron densities in blood samples of breast cancer patients

The main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test. It was found that the electron densities significantly differ between control and breast cancer groups. In addition, statistically significant positive correlation was found between the electron density and Na/K ratios in breast cancer group

CD5 as a prognostic marker in patients with diffuse large B-cell lymphoma: a multicenter study

© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and comprises a heterogeneous group of disease. While classification of B-cell lymphomas has been evolving to include clonality in a specific manner, morphology, and immunohistochemistry remain the backbone. We aimed to evaluate the value of CD5 expression on disease characteristics as well as prognosis in patients with DLBCL. Data of 131 patients with DLBCL with CD5 positivity and as a comparison arm, data of 129 patients with DLBCL without CD5 positivity were evaluated. Mean age was 59 and 55.7% of the patients were male. Overall survival was 29.8 months. Poor prognostic factors including (high-LDH levels, B symptoms, low ECOG score, high R-IPI and NCCN-IPI score) were observed to be significantly related with CD5 positivity. Mean survival in CD5 positive patients were 29.8 months, which is significantly shorter than the general DLBCL survival worldwide. CD5 expression shall be evaluated in all samples of DLBCL patients due to its possible effects on outcomes